Protein kinases display minimal interpositional dependence on substrate sequence: potential implications for the evolution of signalling networks
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چکیده
منابع مشابه
Protein kinases display minimal interpositional dependence on substrate sequence: potential implications for the evolution of signalling networks.
Characterization of in vitro substrates of protein kinases by peptide library screening provides a wealth of information on the substrate specificity of kinases for amino acids at particular positions relative to the site of phosphorylation, but provides no information concerning interdependence among positions. High-throughput techniques have recently made it feasible to identify large numbers...
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ژورنال
عنوان ژورنال: Philosophical Transactions of the Royal Society B: Biological Sciences
سال: 2012
ISSN: 0962-8436,1471-2970
DOI: 10.1098/rstb.2012.0010